United States securities and exchange commission logo February 24, 2021 Bronson Crouch Chief Executive Officer Instil Bio, Inc. 3963 Maple Avenue, Suite 350 Dallas, TX 75219 Re: Instil Bio, Inc. Amendment No. 1 to Draft Registration Statement on Form S-1 Submitted February 12, 2021 CIK 0001789769 Dear Mr. Crouch: We have reviewed your amended draft registration statement and have the following comment. In our comment, we may ask you to provide us with information so we may better understand your disclosure. Please respond to this letter by providing the requested information and either submitting an amended draft registration statement or publicly filing your registration statement on EDGAR. If you do not believe our comment applies to your facts and circumstances or do not believe an amendment is appropriate, please tell us why in your response. After reviewing the information you provide in response to this comment and your amended draft registration statement or filed registration statement, we may have additional comments. Amendment No. 1 to Draft Registration Statement on Form S-1 Prospectus Summary Overview, page 1 1. We note your response to prior comment 6 and re-issue. The term "significant" unmet medical need similarly implies that your products are eligible for fast track designation or priority review granted by the FDA for products that treat certain serious unmet medical needs. You may state, if true, that you are targeting indications with "unmet medical need." Bronson Crouch Instil Bio, Inc. February 24, 2021 Page 2 You may contact Julie Sherman at 202-551-3640 or Vanessa Robertson at 202-551- 3649 if you have questions regarding comments on the financial statements and related matters. Please contact Alan Campbell at 202-551-4224 or Celeste Murphy at 202-551- 3257 with any other questions. Sincerely, FirstName LastNameBronson Crouch Division of Corporation Finance Comapany NameInstil Bio, Inc. Office of Life Sciences February 24, 2021 Page 2 cc: Madison A. Jones FirstName LastName